Santa Monica Vein Center Journal Club
This study explores limitations and prospects for endothelial tissue regeneration using carbon monoxide by direct injection or CO-releasing nanoparticles. Limitations of CO releasing molecules (CORMs) are limited by stability and heavy metal cytotoxicity. Instead, the authors discuss the possiblity of using a CO-rich gold nanoparticle for use. The gold nanoparticle is synthesized by pulsed laser driven CO2 reduction reaction in an aqueous solution. The goal is to induce endothelial cell migration and angiogenesis. This may be a critical pathway to help improve angiogenesis in oxygen deprived tissue.
This study may be an important research foundation for improving blood vasculature and wound repair in recalcitrant wounds.
Raffy Karamanoukian, MD FACS
Santa Monica Vein Center
804 7th Street
Santa Monica, CA 90403