01
FUE Hair Transplants Natural Hair Restoration
Follicular unit extraction (FUE) harvests individual follicular units from the androgen-resistant donor zone of the posterior scalp using a small punch device (0.8–1.0mm), then transplants these DHT-resistant follicles into recipient sites created in the thinning or bald scalp zones. The result is permanent — transplanted follicles retain the genetic programming of their donor site and are not susceptible to the DHT-mediated miniaturization that caused the patient’s original hair loss.
Dr. Karamanoukian’s approach to FUE hairline design reflects his surgical training and aesthetic judgment: single-follicle grafts at the frontal hairline for the most natural, undetectable transition; two and three-follicle units progressively behind the hairline for density; and meticulous recipient site angulation that matches the natural directional growth of the hair at each scalp zone. His donor site management — informed by his scar science expertise — distributes extractions to minimize visible focal alopecia at the donor area and preserve the option for future sessions. PRP is administered intraoperatively to optimize graft survival.
Best For: Stable androgenetic alopecia in men and women with adequate donor density; permanent hair restoration; hairline design and crown density; 3,000–4,000+ graft sessions available; 12–18 months for full results
02
PRP Hair Restoration — Platelet-Rich Plasma
PRP hair restoration is the most extensively studied non-surgical biological treatment for androgenetic alopecia, supported by a substantial published literature including a 2021 meta-analysis of 42 studies comprising 1,569 patients confirming significant improvements in hair density and thickness. A small blood draw is centrifuged to concentrate the platelet fraction 5–10 times above baseline, then injected into the scalp at the follicular bulge depth — delivering concentrated growth factors (PDGF, TGF-β, VEGF, EGF, IGF-1, FGF) that stimulate follicular stem cell activity, prolong the anagen phase, and promote perifollicular neovascularization.
At Kare Plastic Surgery, PRP is prepared using a medical-grade double-centrifuge system and calcium chloride activation to maximize growth factor release from platelet alpha-granules. Dr. Sierro directs the injection protocol, and PRP is offered as a standalone treatment, as a component of the non-surgical hair restoration program alongside Keralase and Nutrafol, and as an intraoperative adjunct during FUE transplantation to accelerate graft survival and optimize growth of transplanted follicles.
Best For: Male and female androgenetic alopecia; alopecia areata complement to medical management; post-pregnancy hair loss acceleration; FUE post-operative graft survival; 3–4 initial sessions, maintenance every 4–6 months
03
Keralase Hair Regeneration
Keralase is a two-step hair restoration treatment that combines the LaseMD Ultra fractional thulium laser (1,927nm) with the application of KeraFactor — a proprietary serum containing a precise blend of biomimetic growth factors and skin proteins including vascular endothelial growth factor (VEGF), epidermal growth factor (EGF), fibroblast growth factor (FGF), keratinocyte growth factor (KGF), and platelet-derived growth factor (PDGF) in liposomal carrier vehicles that enhance follicular penetration.
The fractional thulium laser is applied to the scalp first, creating thousands of microscopic channels in the scalp surface that dramatically increase KeraFactor penetration to the follicular bulge level — delivering growth factor concentrations to the dermal papilla cells that are simply not achievable with topical serum application alone. KeraFactor then signals quiescent follicles to re-enter active growth phase, improves perifollicular microvascular supply, and reduces the inflammatory microenvironment that contributes to ongoing follicular miniaturization. Keralase is particularly valuable for patients who have not responded optimally to PRP alone or who prefer a needle-free scalp treatment.
Best For: Androgenetic alopecia in men and women; needle-free alternative or complement to PRP; monthly sessions for optimal results; safe for all hair types; combined with Nutrafol for comprehensive non-surgical program
04
Nutrafol — Physician-Grade Hair Nutraceutical
Nutrafol is a physician-grade, clinically validated nutraceutical hair health supplement formulated with bioactive botanical ingredients targeting the multiple systemic drivers of hair thinning — including the hormonal (DHT sensitivity), inflammatory, nutritional, and stress pathways that collectively determine hair cycle health. Its core ingredients include Synergen Complex® (ashwagandha KSM-66, saw palmetto, marine collagen, tocotrienol complex, and biotin), clinically validated at the doses contained in the physician-formulated product rather than the diluted doses of retail supplements.
Dr. Sierro prescribes Nutrafol as the foundational daily support supplement for all hair loss patients at Kare, recommending the formulation appropriate for each patient’s specific demographics (Women, Women’s Balance for perimenopausal/postmenopausal patients, Men, and Postpartum for post-delivery patients).
Best For: All hair loss types as foundational daily supplementation; post-pregnancy hair loss support; combined with PRP and Keralase for maximum non-surgical program; physician-prescribed formulation not available retail
05
Microneedling with Exosomes for Scalp
Scalp microneedling with exosome therapy delivers stem cell-derived nano-vesicles containing thousands of growth factors, mRNA transcripts, and microRNA signaling molecules through the micro-channels created by scalp needling — activating Wnt/β-catenin and Sonic Hedgehog signaling pathways that are essential for hair follicle cycling, stimulating VEGF-mediated perifollicular neovascularization, and suppressing the inflammatory signals that drive follicular miniaturization. Published head-to-head data show exosome therapy produces superior hair density improvements compared to PRP alone, with a more potent anti-inflammatory effect that makes it particularly valuable for inflammatory alopecia types including alopecia areata and frontal fibrosing alopecia in stable phase.
Best For: Treatment-resistant androgenetic alopecia; inflammatory alopecia types; maximum biological amplification combined with PRP or Keralase; all hair colors including light and white hair where PRP efficacy is reduced
06
Prescription Hair Loss Medications
Physician-prescribed pharmacologic management is the foundation of the non-surgical hair loss program at Kare Plastic Surgery — providing the DHT suppression and follicular stimulation that biological treatments amplify but cannot replace. Dr. Sierro prescribes Dutasteride (dual 5-alpha reductase inhibitor reducing DHT by more than 90%, superior to Finasteride in published head-to-head trials), Minoxidil (topical 2% and 5%, or low-dose oral 0.5–2.5mg for patients with inadequate topical response), and — for alopecia areata — the FDA-approved JAK inhibitors baricitinib and ritlecitinib that have produced unprecedented response rates for extensive alopecia areata in clinical trials. Every prescription is individualized to the patient’s diagnosis, comorbidities, reproductive status, and treatment goals.
Best For: Androgenetic alopecia in men and women; alopecia areata (JAK inhibitors); combined with PRP and Keralase for maximum medical program; Dutasteride for maximum DHT suppression in male pattern baldness