Kare Plastic Surgery · Dermatology · Santa Monica & Los Angeles
Dermatologist for Daxxify Santa Monica
804 7th Street, Santa Monica, CA 90403 · (310) 998-5533
Daxxify — the longest-lasting FDA-approved neuromodulator — alongside Botox and Xeomin, by board-certified dermatologist Dr. Tiffany Sierro. Results up to 6 months. Same-week appointments.
Call (310) 998-5533 Schedule a Daxxify Appointment
BoardCertified Dermatologist
DaxxifyCertified Injector
Now Available at Kare Plastic Surgery · Santa Monica · Dr. Tiffany Sierro
Daxxify is Here — The Longest-Lasting Neuromodulator Now at Kare
FDA-approved daxibotulinumtoxinA-lanm · Median 6-month duration · Peptide-stabilized · No human albumin · Kare Plastic Surgery, Santa Monica
Daxxify® (daxibotulinumtoxinA-lanm) · Revance · Now at Kare Plastic Surgery, Santa Monica
What Makes Daxxify Different
Daxxify is the first botulinum toxin stabilized with a proprietary peptide (RTP004) rather than human serum albumin. This peptide technology gives Daxxify a significantly longer binding duration to the neuromuscular junction — producing the longest clinical duration of any FDA-approved neuromodulator on the market.
Duration
In Phase 3 clinical trials, Daxxify demonstrated a median duration of 6 months — with 50% of patients maintaining results at 6 months and 23% maintaining results at 9 months. This compares to the 3–4 month standard duration of Botox and Dysport.
FDA Approval
Daxxify received FDA approval in September 2022 for the treatment of moderate-to-severe glabellar frown lines in adults — the first new botulinum toxin approved since 2009. Dr. Sierro offers Daxxify at Kare Plastic Surgery as part of a comprehensive neuromodulator menu.
No Human Albumin
Unlike Botox and Dysport — which use human serum albumin as a stabilizer — Daxxify contains no human or animal-derived proteins beyond the toxin itself. This makes Daxxify an option for patients who prefer albumin-free formulations.
Daxxify • Botox • Xeomin Santa Monica
Three Neuromodulators. One Expert Dermatologist. Every Option Available.
Dr. Tiffany Sierro, MD Board-Certified Dermatologist — Daxxify · Botox · Xeomin Frown Lines · Forehead · Crow's Feet · Lip Flip · Brow Lift · Hyperhidrosis · Kare Plastic Surgery, Santa Monica
Daxxify is the first FDA-approved neuromodulator with a median 6-month duration that fundamentally changes the conversation about wrinkle treatment frequency. For patients who are well-served by Botox or Dysport but find themselves booking every 3–4 months, Daxxify offers the same natural, refreshed results with potentially half the number of annual treatment sessions.
At Kare Plastic Surgery, Dr. Tiffany Sierro, MD offers Daxxify, Botox, Dysport, and Xeomin.
Daxxify vs. Botox vs. Xeomin — The Full Comparison
Active Agent
DaxibotulinumtoxinA-lanm
OnabotulinumtoxinA
IncobotulinumtoxinA
Stabilizer
Peptide (RTP004) — no albumin
Human serum albumin
None — "naked toxin"
Onset
3–5 days
5–7 days
3–5 days
Duration
Up to 6 months
3–4 months
3–4 months
Sessions / Year
~2
3–4
3–4
Best For
Fewer sessions, frown lines
Precision, first-timers
Botox resistance / resistance-prone
Dr. Sierro's selection approach: Daxxify is ideal for established neuromodulator patients who want to reduce treatment frequency and are happy with their current results. Botox remains the gold-standard for first-time patients and those wanting shorter-interval control. Xeomin is reserved for patients who have shown diminishing response to Botox due to antibody formation. Call (310) 998-5533 — Dr. Sierro will recommend the right choice at your consultation.
Kare Plastic Surgery · Santa Monica · (310) 998-5533
Ready to try Daxxify — or compare it to Botox and Xeomin?
Who Is Daxxify For?
Ideal Daxxify Candidates at Kare Plastic Surgery
Established Botox Patients
Patients already using Botox or Dysport with predictable, satisfying results who want to reduce the frequency of treatment sessions from 3–4x per year to approximately 2x per year. Daxxify delivers the same wrinkle relaxation effect with significantly extended duration.
Busy Schedules
Professionals, frequent travelers, and patients who find scheduling quarterly appointments impractical. Daxxify's up-to-6-month duration means fewer office visits per year without sacrificing consistent wrinkle reduction and a refreshed appearance.
Albumin-Free Preference
Patients who prefer formulations without human serum albumin — for personal, ethical, or religious reasons — benefit from Daxxify's unique peptide-stabilized formulation, which contains no human or animal-derived proteins beyond the botulinum toxin itself.
Frown Line Focus
Daxxify is FDA-approved for the treatment of glabellar frown lines — the "11" lines between the brows. Patients with moderate-to-severe frown lines who have been managing them with Botox every 3 months are the most straightforward candidates for switching to Daxxify for extended duration.
Not First-Time Patients
Dr. Sierro generally recommends that first-time neuromodulator patients begin with Botox or Dysport — which allow for shorter-interval adjustment as the optimal dose is established. Once a patient's ideal dose is known, switching to Daxxify for extended duration is a natural next step.
Botox-Resistance Patients
While Xeomin is the primary option for patients with true botulinum toxin antibody resistance (diminishing Botox response over time), Daxxify's novel peptide formulation and unique molecular structure may offer an alternative for some resistance-prone patients. Dr. Sierro evaluates each patient's history individually.
"Daxxify is not a replacement for Botox — it's a better option for a specific type of patient. If you've been happy with your Botox results but you're tired of coming in every 3 months, Daxxify is worth a serious conversation."
— Dr. Tiffany Sierro, MD · Board-Certified Dermatologist · Kare Plastic Surgery, Santa Monica
Frequently Asked Questions
What is Daxxify and how long does it last?
Daxxify is the first peptide-stabilized botulinum toxin neuromodulator, with a median clinical duration of 6 months — approximately twice as long as Botox or Dysport. Some patients maintained results for up to 9 months in clinical trials. FDA-approved for glabellar frown lines. Dr. Sierro offers Daxxify at Kare Plastic Surgery in Santa Monica. Call (310) 998-5533.
How is Daxxify different from Botox and Xeomin?
Daxxify lasts up to 6 months vs. 3–4 months for Botox and Xeomin. Daxxify uses no human albumin — it is stabilized with a proprietary peptide. Xeomin is a "naked toxin" (no accessory proteins) — useful for antibody-resistant patients. Dr. Sierro selects the right neuromodulator based on each patient's goals and history. Call (310) 998-5533.
Is Daxxify safe and who should get it?
Daxxify has the same safety profile as other FDA-approved botulinum toxin neuromodulators and received FDA approval after Phase 2 and Phase 3 clinical trials. Dr. Sierro recommends Daxxify primarily for established neuromodulator patients who are happy with their current results but want to reduce treatment frequency. It is not her first recommendation for first-time neurotoxin patients. Call (310) 998-5533.
Schedule Your Daxxify, Botox, or Xeomin Appointment
Appointments · Kare Plastic Surgery Schedule Daxxify, Botox, or Xeomin with Dr. Sierro →
Same-week Daxxify, Botox, and Xeomin appointments with Dr. Tiffany Sierro at Kare Plastic Surgery, Santa Monica. (310) 998-5533. Serving Los Angeles, Beverly Hills, Brentwood, and Pacific Palisades.
Authority Page · Kare Plastic Surgery Botox & Dysport Los Angeles — Full Treatment Overview →
Complete neuromodulator treatment information — Botox, Dysport, Daxxify, and Xeomin — treatment areas, comparisons, and results by Dr. Tiffany Sierro at Kare Plastic Surgery. (310) 998-5533.
Kare Plastic Surgery · Santa Monica · 804 7th Street
Book Your Daxxify Appointment with Dr. Sierro
Dr. Tiffany Sierro, board-certified dermatologist at Kare Plastic Surgery, provides Daxxify, Botox, Dysport, and Xeomin throughout the Santa Monica and Los Angeles area — natural results, precise technique, and the complete neuromodulator menu to match every patient's goals and lifestyle. Same-week appointments available.